siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles

siRNA-mediated reduction of a circulating protein in swine using lipid nanoparticles

Genetic manipulation of animal models is a fundamental research tool in biology and medicine but is challenging in large animals. In rodents, models can be readily developed by knocking out genes in embryonic stem cells or by knocking down genes through in vivo delivery of nucleic acids. Swine are a...

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Bibliographic Details
Main Authors: Massimo F. Cau, Francesca Ferraresso, Monica Seadler, Katherine Badior, Youjie Zhang, Laura M. Ketelboeter, Geoffrey G. Rodriguez, Taylor Chen, Matteo Ferraresso, Amanda Wietrzny, Madelaine Robertson, Amber Haugen, Pieter R. Cullis, Marc de Moya, Mitchell Dyer, Christian J. Kastrup
Format: Article
Language:English
Published: Elsevier 2024-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
nanomedicine
gene therapy
nucleic acids
fibrinolysis
coagulation
bleeding
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050124000743

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http://www.sciencedirect.com/science/article/pii/S2329050124000743

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