Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes

Protein restriction during pregnancy alters Cdkn1c silencing, dopamine circuitry and offspring behaviour without changing expression of key neuronal marker genes

Abstract We tracked the consequences of in utero protein restriction in mice throughout their development and life course using a luciferase-based allelic reporter of imprinted Cdkn1c. Exposure to gestational low-protein diet (LPD) results in the inappropriate expression of paternally inherited Cdkn...

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Bibliographic Details
Main Authors: Chiara Prodani, Elaine E. Irvine, Alessandro Sardini, Hannah J. Gleneadie, Andrew Dimond, Mathew Van de Pette, Rosalind John, Michelle Kokkinou, Oliver Howes, Dominic J. Withers, Mark A. Ungless, Matthias Merkenschlager, Amanda G. Fisher
Format: Article
Language:English
Published: Nature Portfolio 2024-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-59083-7

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https://doi.org/10.1038/s41598-024-59083-7

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