Gentamicin Blocks the ACh-Induced BK Current in Guinea Pig Type II Vestibular Hair Cells by Competing with Ca2+ at the l-Type Calcium Channel

Gentamicin Blocks the ACh-Induced BK Current in Guinea Pig Type II Vestibular Hair Cells by Competing with Ca2+ at the l-Type Calcium Channel

Type II vestibular hair cells (VHCs II) contain big-conductance Ca2+-dependent K+ channels (BK) and L-type calcium channels. Our previous studies in guinea pig VHCs II indicated that acetylcholine (ACh) evoked the BK current by triggering the influx of Ca2+ ions through l-type Ca2+ channels, which w...

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Bibliographic Details
Main Authors: Hong Yu, Chang-Kai Guo, Yi Wang, Tao Zhou, Wei-Jia Kong
Format: Article
Language:English
Published: MDPI AG 2014-04-01
Series:International Journal of Molecular Sciences
Subjects:
gentamicin
vestibular hair cells
big conductance calcium-dependent potassium channel
acetylcholine
calcium channel
Online Access:http://www.mdpi.com/1422-0067/15/4/6757

Internet

http://www.mdpi.com/1422-0067/15/4/6757

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