Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine

Robust circadian rhythms in organoid cultures from PERIOD2::LUCIFERASE mouse small intestine

Disruption of circadian rhythms is a risk factor for several human gastrointestinal (GI) diseases, ranging from diarrhea to ulcers to cancer. Four-dimensional tissue culture models that faithfully mimic the circadian clock of the GI epithelium would provide an invaluable tool to understand circadian...

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Bibliographic Details
Main Authors: Sean R. Moore, Jill Pruszka, Jefferson Vallance, Eitaro Aihara, Toru Matsuura, Marshall H. Montrose, Noah F. Shroyer, Christian I. Hong
Format: Article
Language:English
Published: The Company of Biologists 2014-09-01
Series:Disease Models & Mechanisms
Subjects:
Circadian rhythm
Intestinal organoid
PERIOD2
R-spondin
RU486
Online Access:http://dmm.biologists.org/content/7/9/1123

Internet

http://dmm.biologists.org/content/7/9/1123

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