Manipulating PP2Acα-ASK-JNK signaling to favor apoptotic over necroptotic hepatocyte fate reduces the extent of necrosis and fibrosis upon acute liver injury

Manipulating PP2Acα-ASK-JNK signaling to favor apoptotic over necroptotic hepatocyte fate reduces the extent of necrosis and fibrosis upon acute liver injury

Abstract In the widely used Carbon tetrachloride (CCl4)-induced acute liver injury (ALI) mouse model, hepatocytes are known to die from programmed cell death (PCD) processes including apoptosis and necroptosis. Both in vivo and in vitro experiments showed that CCl4 treatment could induce both apopto...

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Bibliographic Details
Main Authors: Ke Lu, Si-Yu Shen, Ou-Yang Luo, Yue Lu, Tian-Shu Shi, Jing Wu, Qi Cheng, Hua-Jian Teng, Di Chen, Xiang Lu, Chao-Jun Li, Qing Jiang, Lei Fang, Bin Xue
Format: Article
Language:English
Published: Nature Publishing Group 2022-11-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05353-z

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https://doi.org/10.1038/s41419-022-05353-z

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