Wild-type IDH1 inhibition enhances chemotherapy response in melanoma
Abstract Background Alternative treatment strategies in melanoma beyond immunotherapy and mutation-targeted therapy are urgently needed. Wild-type isocitrate dehydrogenase 1 (wtIDH1) has recently been implicated as a metabolic dependency in cancer. The enzyme protects cancer cells under metabolic st...
Հիմնական հեղինակներ: | , , , , , , , , , |
---|---|
Ձևաչափ: | Հոդված |
Լեզու: | English |
Հրապարակվել է: |
BMC
2022-09-01
|
Շարք: | Journal of Experimental & Clinical Cancer Research |
Խորագրեր: | |
Առցանց հասանելիություն: | https://doi.org/10.1186/s13046-022-02489-w |