Restoration of aberrant gene expression of monocytes in systemic lupus erythematosus via a combined transcriptome-reversal and network-based drug repurposing strategy

Restoration of aberrant gene expression of monocytes in systemic lupus erythematosus via a combined transcriptome-reversal and network-based drug repurposing strategy

Abstract Background Monocytes -key regulators of the innate immune response- are actively involved in the pathogenesis of systemic lupus erythematosus (SLE). We sought to identify novel compounds that might serve as monocyte-directed targeted therapies in SLE. Results We performed mRNA sequencing in...

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Bibliographic Details
Main Authors: Dimitrios Nikolakis, Panagiotis Garantziotis, George Sentis, Antonis Fanouriakis, George Bertsias, Eleni Frangou, Dionysis Nikolopoulos, Aggelos Banos, Dimitrios T Boumpas
Format: Article
Language:English
Published: BMC 2023-04-01
Series:BMC Genomics
Subjects:
Systemic lupus erythematosus
Monocytes
Drug repurposing
Micro RNAs
Transcription factors
Online Access:https://doi.org/10.1186/s12864-023-09275-8

Internet

https://doi.org/10.1186/s12864-023-09275-8

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