TRAF4 Inhibits the Apoptosis and Promotes the Proliferation of Breast Cancer Cells by Inhibiting the Ubiquitination of Spindle Assembly-Associated Protein Eg5

TRAF4 Inhibits the Apoptosis and Promotes the Proliferation of Breast Cancer Cells by Inhibiting the Ubiquitination of Spindle Assembly-Associated Protein Eg5

Tumor necrosis factor receptor associated factor 4 (TRAF4) is a RING domain E3 ubiquitin ligase that mediates the ubiquitination of various proteins and plays an important role in driving tumor progression. By studying the relationship between TRAF4 and Eg5, a member of the kinesin family that plays...

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Bibliographic Details
Main Authors: Miaomiao Hao, Jie Zhang, Mingfang Sun, Kexin Diao, Jian Wang, Shiping Li, Qixue Cao, Shundong Dai, Xiaoyi Mi
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
TRAF4
Eg5
breast cancer
mitosis
ubiquitination
Smurf2
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.855139/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.855139/full

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