Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction

Pan-cancer analysis demonstrates that integrating polygenic risk scores with modifiable risk factors improves risk prediction

Predicting cancer risk requires large datasets and sophisticated models. Here the authors integrate polygenic risk scores and modifiable risk factors for multiple cancers in the UK Biobank, improving general risk prediction and distinguishing cases where genetic or lifestyle factors have stronger as...

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Bibliographic Details
Main Authors: Linda Kachuri, Rebecca E. Graff, Karl Smith-Byrne, Travis J. Meyers, Sara R. Rashkin, Elad Ziv, John S. Witte, Mattias Johansson
Format: Article
Language:English
Published: Nature Portfolio 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19600-4

Internet

https://doi.org/10.1038/s41467-020-19600-4

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