Ameliorative effect of Lactobacillus rhamnosus GG on acetaminophen-induced hepatotoxicity via PKC/Nrf2/PGC-1α pathway

Ameliorative effect of Lactobacillus rhamnosus GG on acetaminophen-induced hepatotoxicity via PKC/Nrf2/PGC-1α pathway

Abstract Background Acetaminophen (APAP) overdose is a common cause of hepatotoxicity. Antioxidants like N-acetyl cysteine are recommended as a therapeutic option; nevertheless, it has limitations. The search for efficient alternatives is ongoing. Probiotics are live microorganisms that maintain a h...

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Bibliographic Details
Main Authors: Hend M. Ahmed, Hanan H. Shehata, Gamila S. M. El-Saeed, Hoda H. Abou Gabal, Sherien M. El-Daly
Format: Article
Language:English
Published: Elsevier 2022-10-01
Series:Journal of Genetic Engineering and Biotechnology
Subjects:
Hepatotoxicity
Acetaminophen
Probiotic
Protein Kinase C
Oxidative stress
Nrf2
Online Access:https://doi.org/10.1186/s43141-022-00422-4

Internet

https://doi.org/10.1186/s43141-022-00422-4

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