Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury

Senescent Schwann cells induced by aging and chronic denervation impair axonal regeneration following peripheral nerve injury

Abstract Following peripheral nerve injury, successful axonal growth and functional recovery require Schwann cell (SC) reprogramming into a reparative phenotype, a process dependent upon c‐Jun transcription factor activation. Unfortunately, axonal regeneration is greatly impaired in aged organisms a...

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Bibliographic Details
Main Authors: Andrés Fuentes‐Flores, Cristian Geronimo‐Olvera, Karina Girardi, David Necuñir‐Ibarra, Sandip Kumar Patel, Joanna Bons, Megan C Wright, Daniel Geschwind, Ahmet Hoke, Jose A Gomez‐Sanchez, Birgit Schilling, Daniela L Rebolledo, Judith Campisi, Felipe A Court
Format: Article
Language:English
Published: Springer Nature 2023-12-01
Series:EMBO Molecular Medicine
Subjects:
aging
chronic denervation
nerve regeneration
Schwann cell
senescence
Online Access:https://doi.org/10.15252/emmm.202317907

Internet

https://doi.org/10.15252/emmm.202317907

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