Losartan to slow the progression of mild-to-moderate Alzheimer’s disease through angiotensin targeting: the RADAR RCT

Losartan to slow the progression of mild-to-moderate Alzheimer’s disease through angiotensin targeting: the RADAR RCT

Background: Medications that modify the renin–angiotensin system may reduce Alzheimer’s disease pathology and reduce the rate of disease progression. Objective: This study investigated whether taking the antihypertensive drug losartan, in addition to normal care, would slow the progression of Alzhei...

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Bibliographic Details
Main Authors: Patrick G Kehoe, Nicholas Turner, Beth Howden, Lina Jarutyt, Shona L Clegg, Ian B Malone, Josephine Barnes, Casper Nielsen, Carole H Sudre, Aileen Wilson, N Jade Thai, Peter S Blair, Elizabeth J Coulthard, J Athene Lane, Peter Passmore, Jodi Taylor, Henk-Jan Mutsaerts, David L Thomas, Nick C Fox, Ian Wilkinson, Yoav Ben-Shlomo
Format: Article
Language:English
Published: NIHR Journals Library 2021-11-01
Series:Efficacy and Mechanism Evaluation
Subjects:
alzheimer’s disease
clinical trial
hypertension
renin–angiotensin system
vascular risk
losartan
mri
Online Access:https://doi.org/10.3310/eme08190

Internet

https://doi.org/10.3310/eme08190

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