Identification of Small Molecules Inhibiting Cardiomyocyte Necrosis and Apoptosis by Autophagy Induction and Metabolism Reprogramming

Identification of Small Molecules Inhibiting Cardiomyocyte Necrosis and Apoptosis by Autophagy Induction and Metabolism Reprogramming

Improvement of anticancer treatments is associated with increased survival of cancer patients at risk of cardiac disease. Therefore, there is an urgent need for new therapeutic molecules capable of preventing acute and long-term cardiotoxicity. Here, using commercial and home-made chemolibraries, we...

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Bibliographic Details
Main Authors: Dawei Liu, Félix Peyre, Yahir Alberto Loissell-Baltazar, Delphine Courilleau, Sandra Lacas-Gervais, Valérie Nicolas, Eric Jacquet, Svetlana Dokudovskaya, Frédéric Taran, Jean-Christophe Cintrat, Catherine Brenner
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Cells
Subjects:
apoptosis
autophagy
cardioprotection
cardiotoxicity
mitochondrion
screening
Online Access:https://www.mdpi.com/2073-4409/11/3/474

Internet

https://www.mdpi.com/2073-4409/11/3/474

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