Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

Single-cell dynamics of pannexin-1-facilitated programmed ATP loss during apoptosis

ATP is essential for all living cells. However, how dead cells lose ATP has not been well investigated. In this study, we developed new FRET biosensors for dual imaging of intracellular ATP level and caspase-3 activity in single apoptotic cultured human cells. We show that the cytosolic ATP level st...

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Bibliographic Details
Main Authors: Hiromi Imamura, Shuichiro Sakamoto, Tomoki Yoshida, Yusuke Matsui, Silvia Penuela, Dale W Laird, Shin Mizukami, Kazuya Kikuchi, Akira Kakizuka
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-10-01
Series:eLife
Subjects:
cell death
energy metabolism
FRET
biosensor
imaging
Online Access:https://elifesciences.org/articles/61960

Internet

https://elifesciences.org/articles/61960

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