Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus.

Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus.

Barrett's esophagus is a premalignant condition whereby the normal stratified squamous esophageal epithelium undergoes a transdifferentiation program resulting in a simple columnar epithelium reminiscent of the small intestine. These changes are typically associated with the stratified squamous...

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Bibliographic Details
Main Authors: Douglas B Stairs, Hiroshi Nakagawa, Andres Klein-Szanto, Shukriyyah D Mitchell, Debra G Silberg, John W Tobias, John P Lynch, Anil K Rustgi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2568822?pdf=render

Internet

http://europepmc.org/articles/PMC2568822?pdf=render

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