HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein

HIV-1 Vpr Induces Degradation of Gelsolin, a Myeloid Cell-Specific Host Factor That Reduces Viral Infectivity by Inhibiting the Expression and Packaging of the HIV-1 Env Glycoprotein

ABSTRACT Gelsolin (GSN) is a structural actin-binding protein that is known to affect actin dynamics in the cell. Using mass spectrometry, we identified GSN as a novel Vpr-interacting protein. Endogenous GSN protein was expressed at detectable levels in monocyte-derived macrophages (MDM) and in THP-...

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Bibliographic Details
Main Authors: Helena Fabryova, Sandra Kao, Sayaka Sukegawa, Eri Miyagi, Louis Taylor, Damien Ferhadian, Hideki Saito, Heiner Schaal, Frank Hillebrand, Klaus Strebel
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mBio
Subjects:
Vpr
gelsolin
human immunodeficiency virus
virus host interactions
Online Access:https://journals.asm.org/doi/10.1128/mbio.02973-22

Internet

https://journals.asm.org/doi/10.1128/mbio.02973-22

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