Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank

Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank

Abstract Background The role of copy number variants (CNVs) in susceptibility to asthma is not well understood. This is, in part, due to the difficulty of accurately measuring CNVs in large enough sample sizes to detect associations. The recent availability of whole-exome sequencing (WES) in large b...

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Bibliographic Details
Main Authors: Katherine A. Fawcett, German Demidov, Nick Shrine, Megan L. Paynton, Stephan Ossowski, Ian Sayers, Louise V. Wain, Edward J. Hollox
Format: Article
Language:English
Published: BMC 2022-05-01
Series:BMC Medical Genomics
Subjects:
Copy number variants
Exome sequencing
UK Biobank
Asthma
Genetic association
Fine-mapping
Online Access:https://doi.org/10.1186/s12920-022-01268-y

Internet

https://doi.org/10.1186/s12920-022-01268-y

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