The TT Genotype of the <i>KIAA1524 rs2278911</i> Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma

The TT Genotype of the <i>KIAA1524 rs2278911</i> Polymorphism Is Associated with Poor Prognosis in Multiple Myeloma

Background: The <i>KIAA1524</i> gene encodes an oncoprotein, CIP2A, which inhibits the phosphorylation of the Akt kinase B, stabilizes the c-Myc protein, and, through that, promotes cancerogenesis. An increase in CIP2A expression has been observed in numerous solid tumors and hematologic...

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Bibliographic Details
Main Authors: Aneta Szudy-Szczyrek, Radosław Mlak, Marcin Mazurek, Tomasz Krajka, Sylwia Chocholska, Paulina Bitkowska, Marta Jutrzenka, Michał Szczyrek, Iwona Homa-Mlak, Andrzej Krajka, Teresa Małecka-Massalska, Marek Hus
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
CIP2A
MYC
multiple myeloma
polymorphism
prognosis
molecular biomarkers
Online Access:https://www.mdpi.com/2073-4409/12/7/1029

Internet

https://www.mdpi.com/2073-4409/12/7/1029

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