Optimized self-microemulsifying drug delivery system improves the oral bioavailability and brain delivery of coenzyme Q10

Optimized self-microemulsifying drug delivery system improves the oral bioavailability and brain delivery of coenzyme Q10

Our study aimed to develop a self-microemulsifying drug delivery system for the poorly aqueous-soluble drug Coenzyme Q10, to improve the dissolution and the oral bioavailability. Excipients were selected based on their Coenzyme Q10 solubility, and their concentrations were set for the optimization o...

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Bibliographic Details
Main Authors: Thapa Chhitij, Jo-Eun Seo, Taekwang Keum, Gyubin Noh, Santosh Bashyal, Shrawani Lamichhane, Jung Hwan Kim, Jae Heon Lee, Jee Hun Park, Jaewoong Choi, Se Hyun Song, Sangkil Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Drug Delivery
Subjects:
Coenzyme Q10
SMEDDS
response surface methodology
D-optimal mixture design
bioavailability
brain distribution
Online Access:https://www.tandfonline.com/doi/10.1080/10717544.2022.2100515

Internet

https://www.tandfonline.com/doi/10.1080/10717544.2022.2100515

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