Neonatal lethality in knockout mice expressing the kinase-dead form of the gefitinib target GAK is caused by pulmonary dysfunction.

Neonatal lethality in knockout mice expressing the kinase-dead form of the gefitinib target GAK is caused by pulmonary dysfunction.

Gefitinib (Iressa) is an inhibitor of the epidermal growth factor receptor (EGFR) that has shown promising activity in the treatment of patients with non-small cell lung cancer (NSCLC). However, adverse side effects of gefitinib treatment, such as respiratory dysfunction, have limited the therapeuti...

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Bibliographic Details
Main Authors: Hiroe Tabara, Yoko Naito, Akihiko Ito, Asako Katsuma, Minami A Sakurai, Shouichi Ohno, Hiroyuki Shimizu, Norikazu Yabuta, Hiroshi Nojima
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3192135?pdf=render

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http://europepmc.org/articles/PMC3192135?pdf=render

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