Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease

Tiagabine is neuroprotective in the N171-82Q and R6/2 mouse models of Huntington's disease

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder characterized by chorea, incoordination, and shortened life-span, and by huntingtin inclusions and neurodegeneration. We previously screened the 1040 FDA-approved compounds from the NINDS compound library and found th...

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Bibliographic Details
Main Authors: Naoki Masuda, Qi Peng, Qing Li, Mali Jiang, Yideng Liang, Xiaofang Wang, Ming Zhao, Wenfei Wang, Christopher A. Ross, Wenzhen Duan
Format: Article
Language:English
Published: Elsevier 2008-06-01
Series:Neurobiology of Disease
Subjects:
Huntington's disease
Tiagabine
Neuroprotection
Transgenic mouse model
Preclinical trials
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108000235

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http://www.sciencedirect.com/science/article/pii/S0969996108000235

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