Synthesis, <sup>123</sup>I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures

Synthesis, <sup>123</sup>I-Radiolabeling Optimization, and Initial Preclinical Evaluation of Novel Urea-Based PSMA Inhibitors with a Tributylstannyl Prosthetic Group in Their Structures

Prostate-specific membrane antigen (PSMA) has been identified as a target for the development of theranostic agents. In our current work, we describe the design and synthesis of novel N-[N-[(S)-1,3-dicarboxypropyl]carbamoyl]-(S)-L-lysine (DCL) urea-based PSMA inhibitors with a chlorine-substituted a...

Full description

Bibliographic Details
Main Authors: Lutfi A. Hasnowo, Maria S. Larkina, Evgenii Plotnikov, Vitalina Bodenko, Feruza Yuldasheva, Elena Stasyuk, Stanislav A. Petrov, Nikolai Y. Zyk, Aleksei E. Machulkin, Nikolai I. Vorozhtsov, Elena K. Beloglazkina, Valentine G. Nenajdenko, Vladimir Tolmachev, Anna Orlova, Alexander G. Majouga, Mekhman S. Yusubov
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:International Journal of Molecular Sciences
Subjects:
DCL ligand
iodine radioisotopes
radiolabeled pharmaceuticals
targeted delivery
prostate-specific membrane antigen
prostate cancer
Online Access:https://www.mdpi.com/1422-0067/24/15/12206

Internet

https://www.mdpi.com/1422-0067/24/15/12206

Similar Items