Tk-deleted pseudorabies virus retains high pathogenicity in rats
The pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion. The aim of the study was to assess the pathogenicity of tk-deleted PRV in rats.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2021-10-01
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| Series: | Journal of Veterinary Research |
| Subjects: | |
| Online Access: | https://doi.org/10.2478/jvetres-2021-0056 |
| _version_ | 1798014018103803904 |
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| author | Zhang Lirong Ruan Keyue Sang Guoju Xu Zhaoyang Tong Wu Yu Hai Shan Tongling Gao Fei Li Liwei Kong Ning Tong Guangzhi Zheng Hao |
| author_facet | Zhang Lirong Ruan Keyue Sang Guoju Xu Zhaoyang Tong Wu Yu Hai Shan Tongling Gao Fei Li Liwei Kong Ning Tong Guangzhi Zheng Hao |
| author_sort | Zhang Lirong |
| collection | DOAJ |
| description | The pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion. The aim of the study was to assess the pathogenicity of tk-deleted PRV in rats. |
| first_indexed | 2024-04-11T15:10:35Z |
| format | Article |
| id | doaj.art-81f792cd31fd4f56b78cdbb0f8e86081 |
| institution | Directory Open Access Journal |
| issn | 2450-8608 |
| language | English |
| last_indexed | 2024-04-11T15:10:35Z |
| publishDate | 2021-10-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Journal of Veterinary Research |
| spelling | doaj.art-81f792cd31fd4f56b78cdbb0f8e860812022-12-22T04:16:39ZengSciendoJournal of Veterinary Research2450-86082021-10-0165440140510.2478/jvetres-2021-0056Tk-deleted pseudorabies virus retains high pathogenicity in ratsZhang Lirong0Ruan Keyue1Sang Guoju2Xu Zhaoyang3Tong Wu4Yu Hai5Shan Tongling6Gao Fei7Li Liwei8Kong Ning9Tong Guangzhi10Zheng Hao11Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, ChinaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, ChinaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, ChinaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, ChinaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, ChinaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, ChinaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, ChinaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, ChinaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, ChinaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, ChinaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, ChinaShanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai200241, ChinaThe pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion. The aim of the study was to assess the pathogenicity of tk-deleted PRV in rats.https://doi.org/10.2478/jvetres-2021-0056pseudorabies virusthymidine kinaserat |
| spellingShingle | Zhang Lirong Ruan Keyue Sang Guoju Xu Zhaoyang Tong Wu Yu Hai Shan Tongling Gao Fei Li Liwei Kong Ning Tong Guangzhi Zheng Hao Tk-deleted pseudorabies virus retains high pathogenicity in rats Journal of Veterinary Research pseudorabies virus thymidine kinase rat |
| title | Tk-deleted pseudorabies virus retains high pathogenicity in rats |
| title_full | Tk-deleted pseudorabies virus retains high pathogenicity in rats |
| title_fullStr | Tk-deleted pseudorabies virus retains high pathogenicity in rats |
| title_full_unstemmed | Tk-deleted pseudorabies virus retains high pathogenicity in rats |
| title_short | Tk-deleted pseudorabies virus retains high pathogenicity in rats |
| title_sort | tk deleted pseudorabies virus retains high pathogenicity in rats |
| topic | pseudorabies virus thymidine kinase rat |
| url | https://doi.org/10.2478/jvetres-2021-0056 |
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