Tk-deleted pseudorabies virus retains high pathogenicity in rats

Tk-deleted pseudorabies virus retains high pathogenicity in rats

The pseudorabies virus (PRV) gene encoding thymidine kinase (tk) is an important virulence-associated factor. Attenuation of PRV in susceptible animals is a frequent result of tk deletion. The aim of the study was to assess the pathogenicity of tk-deleted PRV in rats.

Bibliographic Details
Main Authors: Zhang Lirong, Ruan Keyue, Sang Guoju, Xu Zhaoyang, Tong Wu, Yu Hai, Shan Tongling, Gao Fei, Li Liwei, Kong Ning, Tong Guangzhi, Zheng Hao
Format: Article
Language:English
Published: Sciendo 2021-10-01
Series:Journal of Veterinary Research
Subjects:
pseudorabies virus
thymidine kinase
rat
Online Access:https://doi.org/10.2478/jvetres-2021-0056

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