MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries

MT9, a natural peptide from black mamba venom antagonizes the muscarinic type 2 receptor and reverses the M2R-agonist-induced relaxation in rat and human arteries

All five muscarinic receptors have important physiological roles. The endothelial M2 and M3 subtypes regulate arterial tone through direct coupling to Gq or Gi/o proteins. Yet, we lack selective pharmacological drugs to assess the respective contribution of muscarinic receptors to a given function....

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Bibliographic Details
Main Authors: Justyna Ciolek, Claude Zoukimian, Justine Dhot, Mélanie Burban, Mathilde Triquigneaux, Benjamin Lauzier, Christelle Guimbert, Didier Boturyn, Marine Ferron, Lidia Ciccone, Livia Tepshi, Enrico Stura, Pierre Legrand, Philippe Robin, Gilles Mourier, Béatrice Schaack, Imen Fellah, Guillaume Blanchet, Chantal Gauthier-Erfanian, Rémy Beroud, Denis Servent, Michel De Waard, Nicolas Gilles
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Snake venom
M2 muscarinic receptor
Bioactive peptide mass spectrometry
Peptide sequencing, Drug screening Peptide synthesis
Peptide folding
Arterial pressure
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222004838

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http://www.sciencedirect.com/science/article/pii/S0753332222004838

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