Novel Anti-Melanogenic Compounds, (<i>Z</i>)-5-(Substituted Benzylidene)-4-thioxothiazolidin-2-one Derivatives: In Vitro and In Silico Insights

Novel Anti-Melanogenic Compounds, (<i>Z</i>)-5-(Substituted Benzylidene)-4-thioxothiazolidin-2-one Derivatives: In Vitro and In Silico Insights

To confirm that the β-phenyl-α,β-unsaturated thiocarbonyl (PUSTC) scaffold, similar to the β-phenyl-α,β-unsaturated carbonyl (PUSC) scaffold, acts as a core inhibitory structure for tyrosinase, twelve (<i>Z</i>)-5-(substituted benzylidene)-4-thioxothiazolidin-2-one ((<i>Z</i>...

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Bibliographic Details
Main Authors: Heejeong Choi, Il Young Ryu, Inkyu Choi, Sultan Ullah, Hee Jin Jung, Yujin Park, Yeongmu Jeong, YeJi Hwang, Sojeong Hong, In-Soo Yoon, Hwayoung Yun, Min-Soo Kim, Jin-Wook Yoo, Yunjin Jung, Pusoon Chun, Hyung Ryong Moon
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Molecules
Subjects:
tyrosinase
PUSTC scaffold
anti-melanogenic effect
docking simulation
Online Access:https://www.mdpi.com/1420-3049/26/16/4963

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https://www.mdpi.com/1420-3049/26/16/4963

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