KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway

KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway

Abstract Background Keratins (KRTs) are intermediate filament proteins that interact with multiple regulatory proteins to initiate signaling cascades. Keratin 13 (KRT13) plays an important role in breast cancer progression and metastasis. The objective of this study is to elucidate the mechanism by...

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Bibliographic Details
Main Authors: Lijuan Yin, Qinlong Li, Stefan Mrdenovic, Gina Chia-Yi Chu, Boyang Jason Wu, Hong Bu, Peng Duan, Jayoung Kim, Sungyong You, Michael S. Lewis, Gangning Liang, Ruoxiang Wang, Haiyen E. Zhau, Leland W. K. Chung
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Metastasis
KRT13
Plakoglobin
γ-Catenin
c-Myc
Online Access:https://doi.org/10.1186/s13058-022-01502-6

Internet

https://doi.org/10.1186/s13058-022-01502-6

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