DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation

DNMT3b/OCT4 expression confers sorafenib resistance and poor prognosis of hepatocellular carcinoma through IL-6/STAT3 regulation

Abstract Background The inflammatory cytokine interleukin-6 (IL-6) is critical for the expression of octamer-binding transcription factor 4 (OCT4), which is highly associated with early tumor recurrence and poor prognosis of hepatocellular carcinomas (HCC). DNA methyltransferase (DNMT) family is clo...

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Bibliographic Details
Main Authors: Ssu-Chuan Lai, Yu-Ting Su, Ching-Chi Chi, Yung-Che Kuo, Kam-Fai Lee, Yu-Chih Wu, Pei-Chi Lan, Muh-Hwa Yang, Te-Sheng Chang, Yen-Hua Huang
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Interleukin-6
Phospho-STAT3
OCT4
DNMT3b
Drug resistance
Hepatocellular carcinoma
Online Access:http://link.springer.com/article/10.1186/s13046-019-1442-2

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http://link.springer.com/article/10.1186/s13046-019-1442-2

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