Mice overexpressing β-1,4-Galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis.

Mice overexpressing β-1,4-Galactosyltransferase I are resistant to TNF-induced inflammation and DSS-induced colitis.

Glycosylation is an essential post-translational modification, which determines the function of proteins and important processes such as inflammation. β-1,4-galactosyltransferase I (βGalT1) is a key enzyme involved in the addition of galactose moieties to glycoproteins. Intestinal mucins are glycopr...

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Bibliographic Details
Main Authors: Valerie Vanhooren, Roosmarijn E Vandenbroucke, Sylviane Dewaele, Evelien Van Hamme, Jody J Haigh, Tino Hochepied, Claude Libert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3855152?pdf=render

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http://europepmc.org/articles/PMC3855152?pdf=render

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