Synthesis of 1-(4-phenoxyphenyl)-3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]propan-1-ones as safer anti-inflammatory and analgesic agents
A novel series of 1-(4-phenoxyphenyl)-3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]propan-1-one was synthesized by reaction of 3-(4-phenoxybenzoyl)propionic acid with several aryl acid hydrazides in phosphorus oxychloride. The structures of the compounds were supported by IR, 1H- and 13C-NMR, MS dat...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2008-08-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.shd.org.yu/JSCS/Vol73/No8-9/JSCS-3761.pdf |
| _version_ | 1818835562889478144 |
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| author | ASIF HUSAIN F. J. AHMAD MOHD AJMAL PRIYANKA AHUJA |
| author_facet | ASIF HUSAIN F. J. AHMAD MOHD AJMAL PRIYANKA AHUJA |
| author_sort | ASIF HUSAIN |
| collection | DOAJ |
| description | A novel series of 1-(4-phenoxyphenyl)-3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]propan-1-one was synthesized by reaction of 3-(4-phenoxybenzoyl)propionic acid with several aryl acid hydrazides in phosphorus oxychloride. The structures of the compounds were supported by IR, 1H- and 13C-NMR, MS data and elemental analysis results. These compounds were tested for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. A few compounds were found to have very good anti-inflammatory activity in the carrageenan-induced rat paw edema test, while a fair number of the compounds showed significant analgesic activity in the acetic acid-induced writhing test. These new compounds showed very low ulcerogenic action with reduced malondialdehyde content (MDA), which is one of the by-products of lipid peroxidation. |
| first_indexed | 2024-12-19T02:52:42Z |
| format | Article |
| id | doaj.art-82037fd034824f72bb5a1c8ceaced383 |
| institution | Directory Open Access Journal |
| issn | 0352-5139 |
| language | English |
| last_indexed | 2024-12-19T02:52:42Z |
| publishDate | 2008-08-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-82037fd034824f72bb5a1c8ceaced3832022-12-21T20:38:31ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51392008-08-01738-9781791Synthesis of 1-(4-phenoxyphenyl)-3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]propan-1-ones as safer anti-inflammatory and analgesic agentsASIF HUSAINF. J. AHMADMOHD AJMALPRIYANKA AHUJAA novel series of 1-(4-phenoxyphenyl)-3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]propan-1-one was synthesized by reaction of 3-(4-phenoxybenzoyl)propionic acid with several aryl acid hydrazides in phosphorus oxychloride. The structures of the compounds were supported by IR, 1H- and 13C-NMR, MS data and elemental analysis results. These compounds were tested for their anti-inflammatory, analgesic, ulcerogenic and lipid peroxidation actions. A few compounds were found to have very good anti-inflammatory activity in the carrageenan-induced rat paw edema test, while a fair number of the compounds showed significant analgesic activity in the acetic acid-induced writhing test. These new compounds showed very low ulcerogenic action with reduced malondialdehyde content (MDA), which is one of the by-products of lipid peroxidation.http://www.shd.org.yu/JSCS/Vol73/No8-9/JSCS-3761.pdf134-oxadiazoleanti-inflammatoryanalgesiculcerogeniclipid peroxidation |
| spellingShingle | ASIF HUSAIN F. J. AHMAD MOHD AJMAL PRIYANKA AHUJA Synthesis of 1-(4-phenoxyphenyl)-3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]propan-1-ones as safer anti-inflammatory and analgesic agents Journal of the Serbian Chemical Society 1 3 4-oxadiazole anti-inflammatory analgesic ulcerogenic lipid peroxidation |
| title | Synthesis of 1-(4-phenoxyphenyl)-3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]propan-1-ones as safer anti-inflammatory and analgesic agents |
| title_full | Synthesis of 1-(4-phenoxyphenyl)-3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]propan-1-ones as safer anti-inflammatory and analgesic agents |
| title_fullStr | Synthesis of 1-(4-phenoxyphenyl)-3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]propan-1-ones as safer anti-inflammatory and analgesic agents |
| title_full_unstemmed | Synthesis of 1-(4-phenoxyphenyl)-3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]propan-1-ones as safer anti-inflammatory and analgesic agents |
| title_short | Synthesis of 1-(4-phenoxyphenyl)-3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]propan-1-ones as safer anti-inflammatory and analgesic agents |
| title_sort | synthesis of 1 4 phenoxyphenyl 3 5 substituted aryl 1 3 4 oxadiazol 2 yl propan 1 ones as safer anti inflammatory and analgesic agents |
| topic | 1 3 4-oxadiazole anti-inflammatory analgesic ulcerogenic lipid peroxidation |
| url | http://www.shd.org.yu/JSCS/Vol73/No8-9/JSCS-3761.pdf |
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