Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy

Whole genome sequencing across clinical trials identifies rare coding variants in GPR68 associated with chemotherapy-induced peripheral neuropathy

Abstract Background Dose-limiting toxicities significantly impact the benefit/risk profile of many drugs. Whole genome sequencing (WGS) in patients receiving drugs with dose-limiting toxicities can identify therapeutic hypotheses to prevent these toxicities. Chemotherapy-induced peripheral neuropath...

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Bibliographic Details
Main Authors: Zia Khan, Min Jung, Megan Crow, Rajat Mohindra, Vidya Maiya, Joshua S. Kaminker, David H. Hackos, G. Scott Chandler, Mark I. McCarthy, Tushar Bhangale
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Genome Medicine
Subjects:
Chemotherapy-induced peripheral neuropathy
CIPN
GPR68
GRID2
Cancer
Whole genome sequencing
Online Access:https://doi.org/10.1186/s13073-023-01193-4

Internet

https://doi.org/10.1186/s13073-023-01193-4

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