Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms.

Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms.

Plasma cells constitute the majority of tumor cells in multiple myeloma (MM) but lack the potential for sustained clonogenic growth. In contrast, clonotypic B cells can engraft and recapitulate disease in immunodeficient mice suggesting they serve as the MM cancer stem cell (CSC). These tumor initia...

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Bibliographic Details
Main Authors: Sarah K Brennan, Qiuju Wang, Robert Tressler, Calvin Harley, Ning Go, Ekaterina Bassett, Carol Ann Huff, Richard J Jones, William Matsui
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2931698?pdf=render

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http://europepmc.org/articles/PMC2931698?pdf=render

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