Functional States in Tumor-Initiating Cell Differentiation in Human Colorectal Cancer

Functional States in Tumor-Initiating Cell Differentiation in Human Colorectal Cancer

Intra-tumor heterogeneity of tumor-initiating cell (TIC) activity drives colorectal cancer (CRC) progression and therapy resistance. Here, we used single-cell RNA-sequencing of patient-derived CRC models to decipher distinct cell subpopulations based on their transcriptional profiles. Cell type-spec...

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Bibliographic Details
Main Authors: Martina K. Zowada, Stephan M. Tirier, Sebastian M. Dieter, Teresa G. Krieger, Ava Oberlack, Robert Lorenz Chua, Mario Huerta, Foo Wei Ten, Karin Laaber, Jeongbin Park, Katharina Jechow, Torsten Müller, Mathias Kalxdorf, Mark Kriegsmann, Katharina Kriegsmann, Friederike Herbst, Jeroen Krijgsveld, Martin Schneider, Roland Eils, Hanno Glimm, Christian Conrad, Claudia R. Ball
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
colorectal cancer
tumor-initiating cells
tumor heterogeneity
patient-derived cancer models
single-cell RNA-sequencing
tumor metabolism
Online Access:https://www.mdpi.com/2072-6694/13/5/1097

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https://www.mdpi.com/2072-6694/13/5/1097

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