Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2

Leptin promotes epithelial-mesenchymal transition of breast cancer via the upregulation of pyruvate kinase M2

Abstract Background Accumulating researches have shown that epithelial-mesenchymal transition (EMT) contributes to tumor metastasis. Leptin, a key adipokine secreted from adipocytes, shapes the tumor microenvironment, potentiates the migration of breast cancer cells and angiogenesis, and is also inv...

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Bibliographic Details
Main Authors: Lan Wei, Kuangfa Li, Xueli Pang, Bianqin Guo, Min Su, Yunxiu Huang, Nian Wang, Feihu Ji, Changli Zhong, Junhong Yang, Zhiqian Zhang, Yulin Jiang, Yifeng Liu, Tingmei Chen
Format: Article
Language:English
Published: BMC 2016-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Breast cancer
Leptin
Epithelial-mesenchymal transition
Pyruvate kinase M2
Online Access:http://link.springer.com/article/10.1186/s13046-016-0446-4

Internet

http://link.springer.com/article/10.1186/s13046-016-0446-4

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