Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma

Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma

Abstract Background Lung cancer is the leading cause of cancer death, partially owing to its extensive heterogeneity. The analysis of intertumor heterogeneity has been limited by an inability to concurrently obtain tissue from synchronous metastases unaltered by multiple prior lines of therapy. Meth...

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Bibliographic Details
Main Authors: Runzhe Chen, Jun Li, Junya Fujimoto, Lingzhi Hong, Xin Hu, Kelly Quek, Ming Tang, Akash Mitra, Carmen Behrens, Chi-Wan Chow, Peixin Jiang, Latasha D. Little, Curtis Gumbs, Xingzhi Song, Jianhua Zhang, Dongfeng Tan, John V. Heymach, Ignacio Wistuba, P. Andrew Futreal, Don L. Gibbons, Lauren A. Byers, Jianjun Zhang, Alexandre Reuben
Format: Article
Language:English
Published: BMC 2022-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Lung adenocarcinoma
Intertumor heterogeneity
Genomic
T cell repertoire
Online Access:https://doi.org/10.1186/s13046-022-02361-x

Internet

https://doi.org/10.1186/s13046-022-02361-x

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