SIRT3 Modulates Endothelial Mitochondrial Redox State during Insulin Resistance

SIRT3 Modulates Endothelial Mitochondrial Redox State during Insulin Resistance

Emerging evidence indicates that defects in sirtuin signaling contribute to impaired glucose and lipid metabolism, resulting in insulin resistance (IR) and endothelial dysfunction. Here, we examined the effects of palmitic acid (PA) treatment on mitochondrial sirtuins (SIRT2, SIRT3, SIRT4, and SIRT5...

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Bibliographic Details
Main Authors: Elisa Martino, Anna Balestrieri, Camilla Anastasio, Martina Maione, Luigi Mele, Domenico Cautela, Giuseppe Campanile, Maria Luisa Balestrieri, Nunzia D’Onofrio
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Antioxidants
Subjects:
SIRT3
mitochondria
insulin resistance
endothelial cells
δ-valerobetaine
Online Access:https://www.mdpi.com/2076-3921/11/8/1611

Internet

https://www.mdpi.com/2076-3921/11/8/1611

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