Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+ synthesis by reprogramming H3K79 methylation in uveal melanoma

Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+ synthesis by reprogramming H3K79 methylation in uveal melanoma

Uveal melanoma (UM) is the most frequent and life-threatening ocular malignancy in adults. Aberrant histone methylation contributes to the abnormal transcriptome during oncogenesis. However, a comprehensive understanding of histone methylation patterns and their therapeutic potential in UM remains e...

Full description

Bibliographic Details
Main Authors: Xiang Gu, Yu Hua, Jie Yu, Ludi Yang, Shengfang Ge, Renbing Jia, Peiwei Chai, Ai Zhuang, Xianqun Fan
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Histone methylation
Metabolic reprogramming
Uveal melanoma
Transcriptional addiction
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177922001216

Internet

http://www.sciencedirect.com/science/article/pii/S2095177922001216

Similar Items