Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+ synthesis by reprogramming H3K79 methylation in uveal melanoma

Epigenetic drug library screening reveals targeting DOT1L abrogates NAD+ synthesis by reprogramming H3K79 methylation in uveal melanoma

Uveal melanoma (UM) is the most frequent and life-threatening ocular malignancy in adults. Aberrant histone methylation contributes to the abnormal transcriptome during oncogenesis. However, a comprehensive understanding of histone methylation patterns and their therapeutic potential in UM remains e...

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Bibliographic Details
Main Authors:	Xiang Gu, Yu Hua, Jie Yu, Ludi Yang, Shengfang Ge, Renbing Jia, Peiwei Chai, Ai Zhuang, Xianqun Fan
Format:	Article
Language:	English
Published:	Elsevier 2023-01-01
Series:	Journal of Pharmaceutical Analysis
Subjects:	Histone methylation Metabolic reprogramming Uveal melanoma Transcriptional addiction
Online Access:	http://www.sciencedirect.com/science/article/pii/S2095177922001216

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