Down-regulation of DNA key protein-FEN1 inhibits OSCC growth by affecting immunosuppressive phenotypes via IFN-γ/JAK/STAT-1

Abstract Oral squamous cell carcinoma (OSCC) escape from the immune system is mediated through several immunosuppressive phenotypes that are critical to the initiation and progression of tumors. As a hallmark of cancer, DNA damage repair is closely related to changes in the immunophenotypes of tumor...

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Bibliographic Details
Main Authors: Shimeng Wang, Xiangjian Wang, Jun Sun, Jin Yang, Deyang Wu, Fanglong Wu, Hongmei Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2023-04-01
Series:International Journal of Oral Science
Online Access:https://doi.org/10.1038/s41368-023-00221-8