Structural Insights into the Interaction of Filovirus Glycoproteins with the Endosomal Receptor Niemann-Pick C1: A Computational Study

Structural Insights into the Interaction of Filovirus Glycoproteins with the Endosomal Receptor Niemann-Pick C1: A Computational Study

Filoviruses, including marburgviruses and ebolaviruses, have a single transmembrane glycoprotein (GP) that facilitates their entry into cells. During entry, GP needs to be cleaved by host proteases to expose the receptor-binding site that binds to the endosomal receptor Niemann-Pick C1 (NPC1) protei...

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Bibliographic Details
Main Authors: Manabu Igarashi, Takatsugu Hirokawa, Yoshihiro Takadate, Ayato Takada
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Viruses
Subjects:
filovirus
ebolavirus
marburgvirus
glycoprotein
Niemann-Pick C1
structure
Online Access:https://www.mdpi.com/1999-4915/13/5/913

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https://www.mdpi.com/1999-4915/13/5/913

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