Evaluation of proline-rich antimicrobial peptides as potential lead structures for novel antimycotics against Cryptococcus neoformans

Evaluation of proline-rich antimicrobial peptides as potential lead structures for novel antimycotics against Cryptococcus neoformans

BackgroundCryptococcosis and cryptococcal meningitis, caused by Cryptococcus neoformans infections, lead to approximately 180,000 deaths per year, primarily in developing countries. Individuals with compromised immune systems, e.g., due to HIV infection (AIDS) or chemotherapy, are particularly vulne...

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Bibliographic Details
Main Authors: Alexandra Brakel, Thomas Grochow, Stefanie Fritsche, Daniel Knappe, Andor Krizsan, Simone A. Fietz, Gottfried Alber, Ralf Hoffmann, Uwe Müller
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Microbiology
Subjects:
antifungal peptide
fungal pathogen
intracellular mode-of-action
proline-rich antimicrobial peptide (PrAMP)
scanning electron microscopy
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1328890/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1328890/full

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