Investigating the Potential of Transdermal Delivery of Avanafil Using Vitamin E-TPGS Based Mixed Micelles Loaded Films

Investigating the Potential of Transdermal Delivery of Avanafil Using Vitamin E-TPGS Based Mixed Micelles Loaded Films

To avoid the first-pass metabolism of avanafil (AVA) and its altered absorption in the presence of food after oral administration, this study aimed to investigate the potential of TPGS-based mixed micelle (MM)-loaded film for transdermal delivery and the enhancement of bioavailability. A Box–Behnken...

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Bibliographic Details
Main Authors: Abdullah A. Alamoudi, Osama A. A. Ahmed, Khalid M. El-Say
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Pharmaceutics
Subjects:
bioavailability
erectile dysfunction
transdermal film
PDE5 inhibitors
skin permeation
Online Access:https://www.mdpi.com/1999-4923/13/5/739

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https://www.mdpi.com/1999-4923/13/5/739

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