Novelty in improvement of CAR T cell-based immunotherapy with the aid of CRISPR system

Novelty in improvement of CAR T cell-based immunotherapy with the aid of CRISPR system

Introduction: Chimeric Antigen Receptor (CAR) T cells have tremendous potentials for cancer treatment; however, various challenges impede their universal use. These restrictions include the poor function of T cells in tumor microenvironments, the shortage of tumor-specific antigens and, finally, the...

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Bibliographic Details
Main Authors: Abbas Hajifathali, Maryam Vahdat Lasemi, Maryam Mehravar, Mohammad Reza Moshari, Afshin Mohammad Alizadeh, Elham Roshandel
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Hematology, Transfusion and Cell Therapy
Subjects:
Cancer treatment
Adoptive immunotherapy
Chimeric antigen receptor
Gene therapy
CRISPR/Cas9
Online Access:http://www.sciencedirect.com/science/article/pii/S2531137923001244

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