Differentially mutated subnetworks discovery

Abstract Problem We study the problem of identifying differentially mutated subnetworks of a large gene–gene interaction network, that is, subnetworks that display a significant difference in mutation frequency in two sets of cancer samples. We formally define the associated computational problem an...

Full description

Bibliographic Details
Main Authors: Morteza Chalabi Hajkarim, Eli Upfal, Fabio Vandin
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Algorithms for Molecular Biology
Subjects:
Online Access:http://link.springer.com/article/10.1186/s13015-019-0146-7