An efficient green synthesis of UNA-nucleoside-5′-triphosphates: A versatile synthon for RNA modification with broad therapeutic potential
A facile, reliable, and an efficient “one-pot, two-step” method for the gram-scale chemical synthesis of UNA-nucleoside-5′-triphosphate, starting from the commercially available nucleoside-5′-triphosphate is described. The overall reaction involves oxidation of nucleoside-5′-triphosphate using sodiu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
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| Series: | Results in Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715623000802 |
| Summary: | A facile, reliable, and an efficient “one-pot, two-step” method for the gram-scale chemical synthesis of UNA-nucleoside-5′-triphosphate, starting from the commercially available nucleoside-5′-triphosphate is described. The overall reaction involves oxidation of nucleoside-5′-triphosphate using sodium periodate under aqueous conditions, followed by reduction using sodium borohydride to furnish the corresponding UNA-nucleoside-5′-triphosphate in good yields with high purity. |
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| ISSN: | 2211-7156 |