Artesunate Attenuates Pro-Inflammatory Cytokine Release from Macrophages by Inhibiting TLR4-Mediated Autophagic Activation via the TRAF6-Beclin1-PI3KC3 Pathway

Artesunate Attenuates Pro-Inflammatory Cytokine Release from Macrophages by Inhibiting TLR4-Mediated Autophagic Activation via the TRAF6-Beclin1-PI3KC3 Pathway

Background/Aims: Lipopolysaccharide (LPS) plays a critical role in excessive inflammatory cytokine production during sepsis. Previously, artesunate (AS) was reported to protect septic mice by reducing LPS-induced pro-inflammatory cytokine release. In the present study, the possible mechanism of the...

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Bibliographic Details
Main Authors: Mei Kuang, Yanyan Cen, Rongxin Qin, Shenglan Shang, Zhaoxia Zhai, Chao Liu, Xichun Pan, Hong Zhou
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Artesunate
Lipopolysaccharide
Pro-inflammatory cytokine
Autophagy
TRAF6
Beclin1
PI3KC3
Online Access:https://www.karger.com/Article/FullText/489982

Internet

https://www.karger.com/Article/FullText/489982

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