Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes

<p>Abstract</p> <p>Background</p> <p>MMP-13 and IGFBP-5 are important factors involved in osteoarthritis (OA). We investigated whether two highly predicted microRNAs (miRNAs), miR-140 and miR-27a, regulate these two genes in human OA chondrocytes.</p> <p>Met...

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Bibliographic Details
Main Authors: Duval Nicolas, Pelletier Jean-Pierre, Hum David, Tardif Ginette, Martel-Pelletier Johanne
Format: Article
Language:English
Published: BMC 2009-11-01
Series:BMC Musculoskeletal Disorders
Online Access:http://www.biomedcentral.com/1471-2474/10/148