Variants in <i>COMT</i>, <i>CYP3A5</i>, <i>CYP2B6,</i> and <i>ABCG2</i> Alter Quetiapine Pharmacokinetics

Variants in <i>COMT</i>, <i>CYP3A5</i>, <i>CYP2B6,</i> and <i>ABCG2</i> Alter Quetiapine Pharmacokinetics

Quetiapine is an atypical antipsychotic widely used for the treatment of schizophrenia and the depressive episodes of bipolar disorder. The aim of this work was to investigate the effect of variants in relevant pharmacogenes in the pharmacokinetics of quetiapine and to exploratorily evaluate adverse...

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Bibliographic Details
Main Authors: Pablo Zubiaur, Paula Fernández-Campos, Marcos Navares-Gómez, Paula Soria-Chacartegui, Gonzalo Villapalos-García, Manuel Román, Gina Mejía-Abril, Dolores Ochoa, Francisco Abad-Santos
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceutics
Subjects:
quetiapine
pharmacogenetics
pharmacokinetics
safety
precision medicine
Online Access:https://www.mdpi.com/1999-4923/13/10/1573

Internet

https://www.mdpi.com/1999-4923/13/10/1573

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