Angiotensin II type 1 receptor autoantibody blockade improves cerebral blood flow autoregulation and hypertension in a preclinical model of preeclampsia

Angiotensin II type 1 receptor autoantibody blockade improves cerebral blood flow autoregulation and hypertension in a preclinical model of preeclampsia

Introduction:Women with preeclampsia (PE) and reduced uterine perfusion pressure (RUPP) pre-clinical rat model of PE have elevated angiotensin II type 1 receptor agonistic autoantibodies (AT1-AA) and cerebrovascular dysfunction. Methods:Sprague Dawley rats had RUPP surgery with/without AT1-AA inhibi...

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Bibliographic Details
Main Authors: Jeremy W. Duncan, Daniel Azubuike, George W. Booz, Brandon Fisher, Jan M. Williams, Fan Fan, Tarek Ibrahim, Babbette LaMarca, Mark W. Cunningham
Format: Article
Language:English
Published: Taylor & Francis Group 2020-10-01
Series:Hypertension in Pregnancy
Subjects:
preeclampsia
hypertension
cbf autoregulation
bbb permeability
at1-aa
placental ischemia
Online Access:http://dx.doi.org/10.1080/10641955.2020.1833215

Internet

http://dx.doi.org/10.1080/10641955.2020.1833215

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