Identification of early biological changes in palmitate-treated isolated human islets
Abstract Background Long-term exposure to elevated levels of free fatty acids (FFAs) is deleterious for beta-cell function and may contribute to development of type 2 diabetes mellitus (T2DM). Whereas mechanisms of impaired glucose-stimulated insulin secretion (GSIS) in FFA-treated beta-cells have b...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-08-01
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| Series: | BMC Genomics |
| Online Access: | http://link.springer.com/article/10.1186/s12864-018-5008-z |